Int J Clin Pharm Th
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Int J Clin Pharm Th · Mar 2014
Randomized Controlled TrialEffects of sugammadex on activated partial thromboplastin time and prothrombin time in healthy subjects.
To assess the impact of sugammadex on activated partial thromboplastin time (APTT) and international normalized ratio for prothrombin time (PT(INR)) in healthy subjects and characterize the concentration-dependency of sugammadex effects on APTT and prothrombin time (PT) in normal human plasma in vitro. ⋯ Administration of sugammadex is associated with a dose-related, limited and transient prolongation of APTT and PT(INR) that is unlikely to be of clinical relevance.