Int J Clin Pharm Th
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Int J Clin Pharm Th · Sep 2014
Randomized Controlled Trial Comparative StudyA randomized study of intranasal vs. intravenous infusion of dexmedetomidine in gastroscopy.
To compare the respiratory and circulatory parameters between intranasal and intravenous dexmedetomidine in gastroscopy. ⋯ Intranasal dexmedetomidine is a new, safe, and effective approach for gastroscopy because it has more stable respiratory and circulatory parameters and less adverse reactions than intravenous dexmedetomidine.
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Int J Clin Pharm Th · Sep 2014
Evaluation of etanercept dose reduction in patients with rheumatoid arthritis using pharmacokinetic/pharmacodynamic modeling and simulation.
In this study, we attempt to explore the feasibility of alternative dosing regimens of etanercept in patients with rheumatoid arthritis (RA) using pharmacokinetic/pharmacodynamic (PK/PD) modeling and simulation. ⋯ In this study, the clinical data was well described by the models developed, and several alternative dosing regimens were proposed. Further clinical studies in patients are still needed to confirm our findings.