Int J Clin Pharm Th
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Int J Clin Pharm Th · Jan 2015
Randomized Controlled Trial Comparative Study Clinical TrialHemodynamic responses during induction: comparison of Marsh and Schnider pharmacokinetic models.
Hemodynamic stability is one of the most critical concerns during induction of anesthesia. Whether the pharmacokinetic model by Marsh or the one by Schnider will produce better hemodynamic stability remains unclear. This study compared hemodynamic changes during induction between the two models. ⋯ When target concentrations are titrated according to NI during induction of anesthesia, Marsh's model could induce sedation faster than Schnider's. Meanwhile, hemodynamic changes were not observed to be statistically different between the two models. Hypotension induced by plasma target-controlled infusion of propofol could mainly be attributed to decreased stroke volume instead of vascular dilation.
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Int J Clin Pharm Th · Jan 2015
Case ReportsFirst case report of suspected onset of convulsive seizures due to co-administration of valproic acid and tebipenem.
A patient presented with convulsive seizures when sodium valproate (VPA) and tebipenem pivoxil (Orapenem) were co-administered accidentally. The seizures were suspected to be caused by a reduced concentration of VPA in the blood. ⋯ The results suggest that co-administration of oral carbapenem antibiotics and VPA should be avoided.