Psychopharmacol Bull
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Psychopharmacol Bull · Jan 1991
Randomized Controlled Trial Clinical TrialPredictors of side effects associated with lithium administration in children.
Data were pooled from three controlled and double-blind studies of lithium carbonate involving a total of 48 hospitalized children, and secondary data analyses were conducted. The objective was to assess whether there is a relationship between a child's chronological age and side effects associated with lithium administration. ⋯ For the entire sample of 48 children, the effect of age on side effects was statistically significant (p = .057); younger children had more side effects than older children. This relationship continued to hold after adjustment for weight, serum lithium levels, optimal dose, and duration of optimal dose.