Psychopharmacol Bull
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Psychopharmacol Bull · Jan 1998
Randomized Controlled Trial Clinical TrialAggression classification and treatment response.
This preliminary study investigated whether the aggression subtypes derived from the Aggression Questionnaire (AQ) are related to treatment response. The subjects were 28 aggressive conduct-disordered children (25 males, 3 females), ranging in age from 9.8 to 17.0 years (mean age = 12.69 years), who participated in a double-blind, placebo-controlled study of lithium as a treatment for reducing aggression. We used the Predatory-Affective Index of the AQ to classify subjects into "predatory" (planned) or "affective" (explosive) subtypes of aggression and then related this classification to treatment response. ⋯ However, the Index did significantly differentiate responders and nonresponders during the experimental treatment period, regardless of whether they received lithium or placebo. Treatment response was associated with a more affective and less predatory subtype of aggression. To the best of our knowledge, this is the first study in children to show an association between the aggression subtype and treatment response.
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Psychopharmacol Bull · Jan 1998
ReviewEvaluation of mental health and depression during pregnancy: position paper.
Women in their reproductive years constitute the population at greatest risk for major depression. Consequently, many women will experience depression during the course of conception and pregnancy. ⋯ A small number of rating instruments have been validated among pregnant women and should take precedence in research studies until new instruments are developed specifically for this group. Other issues that require further exploration are risk factors for depression during pregnancy and the course of depression during pregnancy.