The Journal of surgical research
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Meta Analysis
The effect of early goal-directed therapy on mortality in patients with severe sepsis and septic shock: a meta-analysis.
The Surviving Sepsis Campaign has recommended early goal-directed therapy (EGDT) as an essential strategy to decrease mortality among patients with severe sepsis and septic shock. However, three latest multicenter trials failed to show its benefit in the patients with severe sepsis and septic shock. This article was to evaluate the effect of EGDT on the mortality of patients with severe sepsis and septic shock. ⋯ This meta-analysis suggests that EGDT can significantly reduce the mortality among patients with severe sepsis and septic shock.