Arch Gen Psychiat
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Growing evidence indicates that anxiety and depressive disorder onset may involve a prodromal buildup of symptoms. Also, stressful life events may precipitate gradual symptom increase, leading to the development of full-blown disorders. This study used prospective longitudinal data to examine the theory that, over time, stressful events, such as parent-adolescent disagreements, influence the longitudinal course of adolescents' internalizing symptoms, which in turn predict first onset of a depressive or anxiety disorder. ⋯ Among adolescents, persistent or escalating stressful events, such as disagreements with parents, indirectly increase the risk for internalizing disorder onset through their direct association with high or increasing symptom levels. Chronically high or increasing symptom levels directly increase risk for internalizing disorder.
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Comparative Study
Prefrontal dysfunction and treatment response in geriatric depression.
This study investigated the relationship of clinical, neuropsychological, and electrophysiological measures of prefrontal dysfunction with treatment response in elderly patients with major depression. ⋯ Prefrontal dysfunction was associated with poor or delayed antidepressant response in depressed elderly patients. This observation, if confirmed, may aid clinicians in identifying candidates for aggressive somatic therapies and for interventions offering structure of daily activities.