The Journal of thoracic and cardiovascular surgery
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Primary sarcomas of the mediastinum are rare, and data concerning treatment and results of therapy are sparse. ⋯ Because the overall survival for patients with mediastinal sarcomas is 32% and the local recurrence is 64% for tumors completely resected, aggressive adjuvant therapy should continue to be systematically explored.
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J. Thorac. Cardiovasc. Surg. · Mar 1998
Liquid ventilation improves pulmonary function and cardiac output in a neonatal swine model of cardiopulmonary bypass.
Neonatal and infant cardiopulmonary bypass results in multiorgan system dysfunction. Organ protective strategies have traditionally been directed at the myocardium and brain while neglecting the sometimes severe injury to the lungs. We hypothesized that liquid ventilation would improve pulmonary function and cardiac output in neonates after cardiopulmonary bypass. ⋯ Liquid ventilation improved pulmonary function after neonatal cardiopulmonary bypass while increasing cardiac output. The morbidity associated with cardiopulmonary bypass may be significantly reduced if the adverse pulmonary sequelae of bypass can be diminished. Liquid ventilation may become an important technique to protect the lungs from the deleterious effects of cardiopulmonary bypass.
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J. Thorac. Cardiovasc. Surg. · Mar 1998
Sodium/hydrogen exchanger inhibition reduces myocardial reperfusion edema after normothermic cardioplegia.
The hypothesis was that Na+/H+ exchange occurring during normothermic cardioplegia contributes to the development of myocardial edema during subsequent reperfusion and impairs functional recovery. ⋯ Inhibition of the Na+/H+ exchange during normothermic cardioplegia reduces myocardial edema and necrosis during subsequent reperfusion, improving functional recovery. Inhibition of Na+/H+ exchange during reperfusion only has a much smaller effect.
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J. Thorac. Cardiovasc. Surg. · Mar 1998
Simultaneous antegrade and retrograde delivery of continuous warm blood cardioplegia after global ischemia.
Simultaneous delivery of antegrade and retrograde cardioplegia may provide a more homogeneous distribution of cardioplegic solution. It may, however, increase myocardial edema and postcardioplegic myocardial injury. The purpose of this study was to compare simultaneous antegrade-retrograde cardioplegia with antegrade cardioplegia. ⋯ Despite a small increase in myocardial water content induced by simultaneous blood cardioplegia, no impairment of postcardioplegic cardiac function was observed compared with antegrade cardioplegia.