Psychiatr Pol
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Electroconvulsive therapy (ECT) is an effective treatment of severe depression but its mechanism of action is still unknown. The aim of the study was to investigate the effect of first ECT on serum hormone concentrations in patients with severe depression. ⋯ (1) Single electroconvulsive shock insignificantly changes the pituitary-thyroid-adrenal-gonadal axis function. (2) Complicated hormonal changes found before electroconvulsive shock in patients with severe depression suggest the influence of psychotropic treatment as well as the illness on the endocrine system.