Zh Nevrol Psikhiatr
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Zh Nevrol Psikhiatr · Jan 2019
Review[Evaluation of serum neurofilament light chains levels for diagnosis, treatment monitoring and prognosis in multiple sclerosis].
Pathophysiological processes in multiple sclerosis frequently not diagnosed by clinicians become available for analysis only on the basis of paraclinical data (biomarkers). Nowadays neurofilament light chain can be defined as a promising biomarker for multiple sclerosis (MS). Neurofilaments are a structural part of normal neuronal processes consisting of light, intermediate and heavy chains. ⋯ Cutting-edge highly sensitive methods make it possible to detect neurofilament light chains not only in the cerebrospinal fluid but also in the blood serum thus opening the opportunities to utilize them in routine diagnosis in clinical practice. This review comprises existing data on the possible opportunities for research of serum neurofilament light chains in terms of exacerbations, effectiveness of basic therapy, assessment of individual disability, the atrophy of central nervous system structures. Also, there is some information on comparison of two methods: routine MRI of the brain with the contrast agents and detection of serum neurofilament light chains.
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Zh Nevrol Psikhiatr · Jan 2019
[Neurostimulation of the supraorbital nerve with the Cefaly device - a new method for the treatment of migraine].
Treatment of migraine mainly includes pharmacological approaches aimed at breaking migraine attacks and preventive treatment to reduce their frequency. Despite the wide range of pharmacological agents, frequent side effects and pharmacotherapy resistance in patients with migraine determine the urgency of finding new alternative treatment strategies. ⋯ Stimulation of the supraorbital nerve with the percutaneous Cefaly device ('Cefaly Technology sprl', Seraing, Belgium) in clinical randomized, controlled studies has demonstrated efficacy in significantly reducing both the frequency of migraine attacks and the total number of days with headache. Cefaly is the first FDA approved migraine prevention medical device.
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Zh Nevrol Psikhiatr · Jan 2019
[Assessment of the respiratory muscles strength at various stages of ischemic stroke].
Power characteristics of the respiratory muscles (RM) in the dynamics of ischemic stroke (IS) is an important tool for the early diagnosis of RM dysfunction and development of individual programs for treatment at different stages of rehabilitation.