Zh Nevrol Psikhiatr
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Zh Nevrol Psikhiatr · Jan 2009
Comparative Study[Efficacy of gabapentin in patients with discogenic lumbosacral radiculopathy].
Optimal conservative therapy of discogenic lumbosacral radiculopathy is a matter of debates. Contemporary guidelines recommend measures that predominantly have an influence on nociceptive mechanisms. However the mixed nature of pain in patients with discogenic radiculopathy requires approaches used for treatment of neuropathic pain. ⋯ In both groups, the reduction of vertebral syndrome and neuropathic pain characteristics was noticed as well. The clinically significant effect was found in 59% of patients with early onset of treatment with gabapentin and in 51% of patients with later onset. These results suggest that early use of gabapentin (tebantin) holds promises for treatment of discogenic radiculopathy.
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Zh Nevrol Psikhiatr · Jan 2009
Comparative Study[Levetiracetam (keppra) in the treatment of different epileptic syndromes in adults].
One hundred and thirty-eight patients (76 women and 62 men, aged from 16 to 65 years) with symptomatic partial epilepsy (n=128) and idiopathic generalized epilepsy (n=10) have been studied. All patients received keppra on regiments of monotherapy (n=30) and polytherapy (n=108). ⋯ The high effectiveness and tolerability, good characteristics of therapy duration, the early appearance of clinical effect after the therapy has been started and positive cognitive effect are noted. The effectiveness, tolerance and clinical features of keppra treatment in different epileptic syndromes are analyzed.
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Zh Nevrol Psikhiatr · Jan 2008
[The treatment of cerebral aneurysm in elderly patients in the acute period of subarachnoid hemorrhage].
Seven hundreds and forty-nine patients after subarachnoid hemorrhage developed as a result of the rupture of cerebral aneurysm, including 117 (15.6%) people aged 60 years and over (elderly patients) and 632 (83.4%) patients younger than 60 years old, were examined. In these groups severity of a patient's state before the surgery, presence of concomitant pathology, data of instrumental examination, outcome of the surgery were compared. The fatal outcome after the surgery was higher in elderly patients than in younger ones (17.4% versus 12.4%) that might be explained by the greater severity of their state after the development of subarachnoid hemorrhage and higher incidence of hypertensive disease and other concomitant diseases. Clinically significant angiospasm and non-resorptive hydrocephalus were observed in this group most frequently.