The Journal of pharmacy and pharmacology
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J. Pharm. Pharmacol. · Dec 1995
Comparative StudyEffects of clonidine pretreatment on the local anaesthetic activity of bupivacaine in mice.
This study was designed to document possible changes in bupivacaine local anaesthetic activity in mice after a single injection of clonidine (0.1 or 1 mgkg-1, i.p.). The local anaesthetic activity was evaluated during 60 min, according to a previously reported technique, using sciatic nerve blockade by injection of bupivacaine in the area of the sciatic nerve. ⋯ The maximal effect (Emax) was significantly lower for the pretreated group (1.15 +/- 0.13 units, 0.1 mgkg-1; 1.35 +/- 0.09 units, 1 mgkg-1) compared with the control group (1.72 +/- 0.13, P = 0.01). Our data indicate a significant decrease in the duration of anaesthetic activity of bupivacaine in clonidine-pretreated mice.