The Journal of pharmacy and pharmacology
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J. Pharm. Pharmacol. · Jun 2009
Evaluation of population pharmacokinetic models for amikacin dosage individualization in critically ill patients.
The aim of this study was to evaluate the reliability for dosage individualization and Bayesian adaptive control of several literature-retrieved amikacin population pharmacokinetic models in patients who were critically ill. ⋯ Only a single amikacin serum level seemed necessary to diminish the influence of population model on dosage individualization.