The Journal of pharmacy and pharmacology
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J. Pharm. Pharmacol. · Aug 2011
Pre-emptive intrathecal quinidine alleviates spinal nerve ligation-induced peripheral neuropathic pain.
Quinidine, a class I anti-arrhythmic agent, is a sodium channel blocker that is more potent than lidocaine and mexiletine. This study tested pre-emptive intrathecal quinidine to attenuate neuropathic pain induced by lumbar spinal nerve ligation (SNL). ⋯ Pretreatment with intrathecal quinidine 70 mM before SNL attenuates nerve ligation-induced neuropathic pain. The duration of the effect is 5 days.
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J. Pharm. Pharmacol. · Aug 2011
Anti-inflammatory, analgesic and antipyretic effects of friedelin isolated from Azima tetracantha Lam. in mouse and rat models.
Friedelin was isolated from Azima tetracantha Lam. leaves collected from Kallakurichi, Villuppuram district, Tamil Nadu, India. The anti-inflammatory, analgesic and antipyretic activities of friedelin have been investigated in Wistar rats and mice. ⋯ The results suggested that friedelin possessed potent anti-inflammatory, analgesic and antipyretic activities.