The Journal of pharmacy and pharmacology
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J. Pharm. Pharmacol. · Feb 2012
Effects of isoflurane on learning and memory functions of wild-type and glutamate transporter type 3 knockout mice.
General anesthetics may contribute to the post-operative cognitive dysfunction. This study was designed to determine the effects of isoflurane on the learning and memory of healthy animals or animals with a decreased brain antioxidative capacity. ⋯ These results suggest that EAAT3 knockout mice have significant cognitive impairment. Isoflurane may not significantly affect the cognition of wild-type and EAAT3 knockout mice in a delayed phase after isoflurane exposure.