The Journal of pharmacy and pharmacology
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J. Pharm. Pharmacol. · Jul 2014
Targeting interleukin-1β reduces intense acute swimming-induced muscle mechanical hyperalgesia in mice.
The role of interleukin (IL)-1β in intense acute swimming-induced muscle mechanical hyperalgesia was investigated in mice. ⋯ IL-1β mediates intense acute swimming-induced muscle mechanical hyperalgesia by peripheral (soleus muscle) and spinal cord integrative mechanisms and could be considered a potential target to treat exercise-induced muscle pain.