Plos One
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Observational Study
Prognostic value of plasma pentraxin 3 levels in patients with septic shock admitted to intensive care.
To evaluate the usefulness of a new marker, pentraxin, as a prognostic marker in septic shock patients. ⋯ Our results support the prognostic value of a single determination of plasma PTX3 as a predictor of hospital mortality in septic shock patients.
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Observational Study
The first wave of COVID-19 in Malta; a national cross-sectional study.
The COVID-19 pandemic has posed major challenges to all aspects of healthcare. Malta's population density, large proportion of elderly and high prevalence of diabetes and obesity put the country at risk of uncontrolled viral transmission and high mortality. Despite this, Malta achieved low mortality rates compared to figures overseas. The aim of this paper is to identify key factors that contributed to these favorable outcomes. ⋯ Effective public health interventions, widespread testing, remote surveillance of patients in the community and a low threshold for admission are likely to have contributed to these favorable outcomes. Hospital infection control measures were key in preventing significant nosocomial spread. These concepts can potentially be applied to stem future outbreaks of viral diseases. Patients with moderate-severe disease had excellent outcomes with no deaths reported at 30-day follow up.
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The coronavirus disease 2019 is a respiratory illness spread between people. A primary weapon for reducing or eliminating this disease involves physical distancing to thwart transmission. ⋯ Devising a configuration of desks and/or workspaces that are physically distant is a type of dispersion problem that can be formalized mathematically and solved. Planning efforts for a university campus serve to illustrate how spatial optimization can support safety enhancements.
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Finite element models combined with animal experimental models of spinal cord injury provides the opportunity for investigating the effects of the injury mechanism on the neural tissue deformation and the resulting tissue damage. Thus, we developed a finite element model of the mouse cervical spinal cord in order to investigate the effect of morphological, experimental and mechanical factors on the spinal cord mechanical behavior subjected to transverse contusion. ⋯ Pareto analysis revealed that the material properties had a significant effect (p<0.01) for all regions of interest of the spinal cord and was the most influential factor for 7 out of 8 regions. This highlighted the need for comprehensive mechanical characterization of the gray and white matter in order to develop effective models capable of predicting tissue deformation during spinal cord injuries.