Pediatrics
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Randomized Controlled Trial Multicenter Study
Clonidine as an adjunct therapy to opioids for neonatal abstinence syndrome: a randomized, controlled trial.
To determine if oral clonidine would reduce the duration of opioid detoxification for neonatal abstinence syndrome. ⋯ In this randomized, double-blind trial, adding clonidine to standard opioid therapy for detoxification from in utero exposure to methadone or heroin reduced the duration of pharmacotherapy for neonatal abstinence without causing short-term adverse cardiovascular outcomes. A larger trial is indicated to determine long-term safety.