Pediatrics
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Multicenter Study
Multicenter crossover study of automated control of inspired oxygen in ventilated preterm infants.
To determine the efficacy and safety of automated adjustment of the fraction of inspired oxygen (Fio(2)) adjustment in maintaining arterial oxygen saturation (Spo(2)) within an intended range for mechanically ventilated preterm infants with frequent episodes of decreased Spo(2). ⋯ In infants with fluctuations in Spo(2), automated Fio(2) adjustment improved maintenance of the intended Spo(2) range led to reduced time with high Spo(2) and more-frequent episodes with Spo(2) between 80% and 86%.
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Multicenter Study
Early-childhood neurodevelopmental outcomes are not improving for infants born at <25 weeks' gestational age.
We compared neurodevelopmental outcomes at 18 to 22 months' corrected age of infants born with extremely low birth weight at an estimated gestational age of <25 weeks during 2 periods: 1999-2001 (epoch 1) and 2002-2004 (epoch 2). ⋯ Early-childhood outcomes for infants born at <25 weeks' estimated gestational age were unchanged between the 2 periods.