Neuroendocrinol Lett
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Neuroendocrinol Lett · Jun 2001
Melatonin inhibits spontaneous and oxytocin-induced contractions of rat myometrium in vitro.
The aim of this study was to investigate the effects of melatonin on spontaneous and oxytocin-induced contractility of pregnant and non-pregnant rat myometrium in vitro. ⋯ Data from this study demonstrates that melatonin inhibits spontaneous and oxytocin-induced contractions of myometrium from pregnant and non-pregnant rats. Although the exact mechanism is not clear, melatonin-induced inhibition of myometrial contractions may results from its interactions with Ca(2+) channels.