Jpen Parenter Enter
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Jpen Parenter Enter · Sep 1999
Blood clearance and tissue uptake of intravenous lipid emulsions containing long-chain and medium-chain triglycerides and fish oil in a mouse model.
Increasing interest in using different triglycerides (TGs) for specific clinical applications raised the question as to how the emulsion TG composition would affect blood clearance and emulsion delivery to hepatic and extrahepatic tissues. ⋯ Results indicate slow blood clearance of pure omega-3 TG emulsion from the blood compared with emulsion in which omega-3 TG was mixed with LCT and MCT. Earlier data showed that omega-3 TG are poorly hydrolyzed in extracellular media and therefore are delivered to tissues as part of the core of emulsion remnants. Thus, our data suggest that the incorporation of omega-3 TG with LCT/MCT will result in greater delivery of omega-3 fatty acids to extrahepatic tissue, which could be important in modulating immune and other responses.