Jpen Parenter Enter
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Jpen Parenter Enter · Nov 2004
Serum levels of interleukin-6 and C-reactive protein correlate with body mass index across the broad range of obesity.
It has been noted that elevated inflammatory markers, such as tumor necrosis factor-alpha (TNF), soluble TNF receptor II (sTNF-RII), interleukin 6 (IL-6) and C-reactive protein (CRP), are characteristically found in the serum in obese patients. In this study, we examined the correlation of these markers with BMI in nonobese, obese, and morbidly obese individuals to explore this relationship across the broad range of obesity. ⋯ The present results support evidence that obesity represents an inflammatory state. In morbid obesity, the correlation of only IL-6 and CRP with BMI, particularly in males, suggests that IL-6 may be secreted in an endocrine manner in proportion to the expansion of fat mass particularly in the abdominal region, with a corresponding increase in hepatic production of CRP.
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Jpen Parenter Enter · Nov 2004
Standard equations are not accurate in assessing resting energy expenditure in patients with amyotrophic lateral sclerosis.
To assess the utility of standard equations for calculating caloric requirements in patients with amyotrophic lateral sclerosis (ALS). ⋯ We found that standard equations used to calculate energy expenditure were not valid for patients with ALS. Moreover, the majority of our patients were either overfed or underfed. As underfeeding can cause diaphragm impairment, and overfeeding can increase ventilatory load, indirect calorimetry should be considered in ALS patients to determine optimal caloric requirement.