Jpen Parenter Enter
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Jpen Parenter Enter · Jul 2006
The incidence and impact of dextrose dose on hyperglycemia from parenteral nutrition (PN) exposure in hematopoietic stem cell transplant (HSCT) recipients.
Short-term, transient hyperglycemia is associated with adverse outcomes in acutely ill populations. Because parenteral nutrition (PN) is dextrose based, we hypothesized that exposure to PN would be associated with hyperglycemia and that greater levels of dextrose infusion would be associated with higher glucose concentrations. Our objective was to examine the temporality, incidence, and dose response from dextrose load upon hyperglycemia using several serum glucose cut points in PN vs non-PN HSCT recipients. ⋯ The broad use of PN at levels within current clinical guidelines in HSCT adults was associated with profound hyperglycemia; however, greater dextrose dose, within the narrow levels administered in this cohort, was not associated with higher glucose concentrations.
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Jpen Parenter Enter · Jul 2006
Olive oil-based lipid emulsion's neutral effects on neutrophil functions and leukocyte-endothelial cell interactions.
Infection remains a drawback of parenteral nutrition (PN), probably related, among other factors, to immunosuppressive effects of its lipid component. Newer preparations may have lesser immunosuppressive impact. This study examines the effects of an olive oil-based lipid emulsion (long-chain triacylglycerols-monounsaturated fatty acids [LCT-MUFA]; ClinOleic) on various functions of human neutrophils in vitro and on rat leukocyte-endothelial cell interactions in vivo compared with LCT (Intralipid) and 50% LCT-50% medium-chain triacylglycerols (MCT; Lipofundin) mixture. ⋯ LCT-MUFA showed lower in vitro and in vivo impact on neutrophil function compared with LCT and LCT-MCT.