Jpen Parenter Enter
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Jpen Parenter Enter · Mar 2007
Optimizing the dose of glutamine dipeptides and antioxidants in critically ill patients: a phase I dose-finding study.
Supplementation with glutamine and antioxidants may be associated with an improvement in clinical outcomes, but the optimal dose of these substrates is unknown. The purpose of this study was to determine the safety of high doses of glutamine combined with antioxidants in critically ill patients. ⋯ The doses of glutamine and antioxidants tested in this study seem to be safe and may have positive effects on some mechanistic endpoints. A larger trial will be necessary to confirm their therapeutic effects.
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Jpen Parenter Enter · Mar 2007
Randomized Controlled TrialSynbiotics, prebiotics, glutamine, or peptide in early enteral nutrition: a randomized study in trauma patients.
Since the hepatosplanchnic region plays a central role in development of multiple-organ failure and infections in critically ill trauma patients, this study focuses on the influence of glutamine, peptide, and synbiotics on intestinal permeability and clinical outcome. ⋯ Patients supplemented with synbiotics did better than the others, with lower intestinal permeability and fewer infections.