Jpen Parenter Enter
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Jpen Parenter Enter · Mar 2011
Multicenter StudyWhen early enteral feeding is not possible in critically ill patients: results of a multicenter observational study.
Early enteral nutrition (EN) is the preferred strategy for feeding the critically ill; however, it is not always possible to initiate EN within the recommended 24 to 48 hours. When these situations arise, controversy exists whether to start feeding early via the parenteral route or to delay feeding until EN can be provided. ⋯ The results suggest that initiating PN early, when it is not possible to feed enterally early, may improve provision of calories and protein but is not associated with better clinical outcomes compared with late EN or PN.
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Jpen Parenter Enter · Mar 2011
Nutrition status and risk factors associated with length of hospital stay for surgical patients.
To diagnose the nutrition status of hospitalized patients and identify the risk factors associated with hospital length of stay (LOS). ⋯ LOS was associated with disease and nutrition status. Among the more common diseases, nutrition status according to the subjective approach determined the LOS for patients with DTD and nutrition status according to arm circumference determined the LOS for patients with neoplasms.
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Jpen Parenter Enter · Mar 2011
Glutamine restores myocardial cytochrome C oxidase activity and improves cardiac function during experimental sepsis.
Cardiac dysfunction occurs commonly in sepsis. Impaired mitochondrial function is a potential cause of sepsis-associated myocardial depression. Cytochrome oxidase (COX), the terminal oxidase of the electron transport chain, is inhibited in the septic heart. Glutamine (GLN) increases Krebs cycle intermediates and supports oxidative phosphorylation. Exogenous GLN has been shown to restore myocardial adenosine triphosphate levels and cardiac function following ischemia-reperfusion injury. The authors hypothesize that exogenous GLN will abrogate sepsis-induced myocardial COX inhibition and improve sepsis-associated myocardial depression. ⋯ The beneficial effects of GLN therapy during sepsis may be in part due to restoration of oxidative phosphorylation and abrogation of sepsis-associated myocardial depression.