Jpen Parenter Enter
-
Jpen Parenter Enter · May 2013
Review Meta AnalysisThe effects of probiotics in early enteral nutrition on the outcomes of trauma: a meta-analysis of randomized controlled trials.
The role of probiotics in trauma patients remains unclear. We undertook a meta-analysis of published randomized controlled trials (RCTs) to assess the effects of probiotics on the clinical outcomes of trauma patients. ⋯ The use of probiotics is associated with a reduction in the incidence of nosocomial infections, VAP, and length of ICU stay but is not associated with an overall mortality advantage. However, the results should be interpreted cautiously due to the heterogeneity among study designs. Further large-scale, well-designed RCTs are needed.