Jpen Parenter Enter
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Jpen Parenter Enter · Aug 2014
Randomized Controlled TrialPreliminary safety and efficacy of L-carnitine infusion for the treatment of vasopressor-dependent septic shock: a randomized control trial.
Sepsis is characterized by metabolic disturbances, and previous data suggest a relative carnitine deficiency may contribute to metabolic dysfunction. Studies regarding safety and patient-centered efficacy of carnitine during septic shock are lacking. ⋯ L-carnitine infusion appears safe in vasopressor-dependent septic shock. Preliminary efficacy data suggest potential benefit of L-carnitine treatment, and further testing is indicated.
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Jpen Parenter Enter · Aug 2014
Clinical TrialPediatric intestinal failure-associated liver disease is reversed with 6 months of intravenous fish oil.
Studies have suggested that when intravenous (IV) soybean oil (SO) is replaced with fish oil (FO), direct hyperbilirubinemia is more likely to resolve. The necessary duration of FO has not been established. This study seeks to determine if 24 weeks of FO is an effective and safe therapy for intestinal failure-associated liver disease (IFALD). ⋯ A limited duration of FO appears to be safe and effective in reversing IFALD.