Arch Pediat Adol Med

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• Arch Pediat Adol Med · Oct 2007

  Review Meta Analysis

  Hypothermia to treat neonatal hypoxic ischemic encephalopathy: systematic review.

  To systematically review the effectiveness, as determined by survival without moderate to severe neurodevelopmental disability in infancy and childhood, and the safety of hypothermia vs normothermia in neonates with postintrapartum hypoxic-ischemic encephalopathy and to perform subgroup analyses based on severity of encephalopathy (moderate or severe), type of hypothermia (systemic or selective head cooling), and degree of hypothermia (moderate [or=33.6 degrees C]). ⋯ In neonates with postintrapartum asphyxial hypoxic-ischemic encephalopathy, hypothermia is effective in reducing death and moderate to severe neurodevelopmental disability either in combination or separately and is a safe intervention.

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