Bmc Pediatr
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Randomized Controlled Trial Clinical Trial
Morphine for elective endotracheal intubation in neonates: a randomized trial [ISRCTN43546373].
Elective endotracheal intubations are still commonly performed without premedication in many institutions. The hypothesis tested in this study was that morphine given prior to elective intubations in neonates would decrease fluctuations in vital signs, shorten the duration of intubation and reduce the number of attempts. ⋯ We failed to demonstrate the effectiveness of morphine in reducing the physiological instability or time needed to perform elective intubations. Alternatives, perhaps with more rapid onset of action, should be considered.