Pediatr Crit Care Me
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Pediatr Crit Care Me · Sep 2004
Review Meta Analysis Comparative StudyEfficacy of interventions for bronchiolitis in critically ill infants: a systematic review and meta-analysis.
Viral bronchiolitis is the leading cause of respiratory failure among infants in the United States. Currently, the mainstay of treatment is supportive care. The effectiveness of treatments used for mechanically ventilated infants with bronchiolitis is unclear. ⋯ Currently, there are no clearly effective interventions available to improve the outcome of critically ill infants with bronchiolitis. Surfactant seems to be a promising intervention, and corticosteroids or ribavirin may also be beneficial.
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Pediatr Crit Care Me · Sep 2004
Comparative StudyCerebral blood flow and oxygenation during venoarterial and venovenous extracorporeal membrane oxygenation in the newborn lamb.
Concern exists that extracorporeal membrane oxygenation (ECMO) may decrease cerebral blood flow (CBF), impair cerebral autoregulation, and thereby increase the risk of neurologic injury. ⋯ There was no sustained decrease in CBF after ligation of either the carotid artery or jugular vein. Venoarterial but not venovenous ECMO induced decreases of CBF that could not be attributed to changes in blood gases or blood pressure but that may relate to diminished pulsatility in cerebral resistance vessels or to differences in levels of circulating vasoactive compounds.
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Pediatr Crit Care Me · Sep 2004
Editorial Comment Comparative StudyExtracorporeal cardiopulmonary resuscitation: ready for prime time?
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Pediatr Crit Care Me · Sep 2004
Clinical TrialPharmacokinetics of levosimendan in pediatric patients evaluated for cardiac surgery.
The objective of the study was to evaluate the pharmacokinetics, hemodynamic effects, and safety of levosimendan in children with congenital heart disease. ⋯ The pharmacokinetic profile of levosimendan in children with congenital heart disease is similar to that in adult patients with congestive heart failure. The minimal hemodynamic efficacy after the 12 microg/kg levosimendan bolus was probably due to a small dose relative to body surface area.