Pediatr Crit Care Me
-
Pediatr Crit Care Me · Mar 2008
Pediatric organ donation: what factors most influence parents' donation decisions?
To identify factors that influence parents' decisions when asked to donate a deceased child's organs. ⋯ This study identifies several modifiable variables that influence the donation decision-making process for parents. Strategies to facilitate targeted organ donation education and higher consent rates are discussed.
-
Pediatr Crit Care Me · Mar 2008
Randomized Controlled TrialCombination of recombinant human growth hormone and propranolol decreases hypermetabolism and inflammation in severely burned children.
Recombinant human growth hormone (rhGH) is a salutary modulator of posttraumatic metabolic responses. However, rhGH administration is associated with deleterious side effects, such as hyperglycemia, increased free fatty acids, and triglycerides, which limit its use. Administration of beta-blocker attenuates cardiac work and resting energy expenditure after severe thermal injury and improves fat metabolism and insulin sensitivity. Therefore, the combination of rhGH plus propranolol appears ideal. The aim of the present study was to determine whether rhGH plus propranolol improves hypermetabolism and the inflammatory and acute phase response after severe burn without causing adverse side effects. ⋯ rhGH in combination with propranolol attenuates hypermetabolism and inflammation without the adverse side effects found with rhGH therapy alone.
-
Pediatr Crit Care Me · Mar 2008
Glucose control, organ failure, and mortality in pediatric intensive care.
In ventilated children, to determine the prevalence of hyperglycemia, establish whether it is associated with organ failure, and document glycemic control practices in Australasian pediatric intensive care units (PICUs). ⋯ Hyperglycemia is common in PICUs, occurs early, and is independently associated with organ failure and death. However, early hyperglycemia is not associated with later or worsening organ failure. Australasian PICUs seldom use insulin.
-
Pediatr Crit Care Me · Mar 2008
Prospective detection of hyperglycemia in critically ill children using continuous glucose monitoring.
To evaluate the extent of hyperglycemia in nondiabetic children admitted to a pediatric intensive care unit using an interstitial continuous glucose monitor, and to compare the ability of this interstitial continuous glucose monitoring system to detect hyperglycemia with that of intermittent laboratory monitoring. ⋯ Significant hyperglycemia is present in pediatric intensive care patients and may be underestimated by intermittent laboratory monitoring.