Pediatr Crit Care Me
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Pediatr Crit Care Me · Jul 2008
Procalcitonin and C-reactive protein as markers of bacterial infection in critically ill children at onset of systemic inflammatory response syndrome.
To compare the accuracy of procalcitonin and C-reactive protein as diagnostic markers of bacterial infection in critically ill children at the onset of systemic inflammatory response syndrome (SIRS). ⋯ Procalcitonin is better than C-reactive protein for differentiating bacterial from nonbacterial SIRS in critically ill children, although the accuracy of both tests is moderate. Diagnostic accuracy could be enhanced by combining these tests with bedside clinical judgment.
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Pediatr Crit Care Me · Jul 2008
Extracorporeal life support for severe respiratory failure in children with immune compromised conditions.
To examine a large cohort of children treated with extracorporeal life support (ECLS) for severe respiratory failure to investigate the hypothesis that patients with an immune compromise condition (ICC) would have reduced survival to hospital discharge compared with patients without this classification. ⋯ In this cohort of pediatric patients receiving ECLS for respiratory failure, survival to hospital discharge was reduced for each ICC subgroup examined and was approximately one in three for the overall group. Further study of the association of lower survival rates for patients who received inhaled nitric oxide prior to ECLS is needed.
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Pediatr Crit Care Me · Jul 2008
Renal effects of fenoldopam in critically ill pediatric patients: A retrospective review.
Published data describe the use of fenoldopam in adults for treatment of oliguria/anuria and for renal perfusion and protection, but pediatric data are scant. We assessed the effects of fenoldopam on urine output and potential deleterious changes in hemodynamics or serum creatinine in children. ⋯ Fenoldopam increases urine output in select critically ill pediatric patients without requiring escalation of inotropic support. There were no adverse hemodynamic effects or alterations in serum creatinine. Further prospective pediatric studies to define the role of fenoldopam in children are warranted.