Pediatr Crit Care Me
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Pediatr Crit Care Me · Jun 2019
The Fragility of Statistically Significant Findings in Pediatric Critical Care Randomized Controlled Trials.
The Fragility Index measures the number of events on which the statistical significance of a result depends and has been suggested as an adjunct statistical assessment for interpretation of trial results. This study aimed to assess the robustness of statistically significant results from pediatric critical care randomized controlled trials with dichotomous outcomes. ⋯ Results from pediatric critical care randomized controlled trials with dichotomous outcomes reporting statistically significant findings often hinge on a small number of outcome events. Clinicians should exercise caution when interpreting results of trials with a low Fragility Index.