Pediatr Crit Care Me
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Pediatr Crit Care Me · Jun 2020
Cholinesterases and Anticholinergic Medications in Postoperative Pediatric Delirium.
To describe the relationships between anticholinergic drug exposure, cholinesterase enzyme activity, inflammation, and the development of postoperative delirium in children. ⋯ Anticholinergic drug exposure was related to development of postoperative delirium in this cohort, with demonstration of a dose-response relationship. As there are alternative options available for many of these medications, it may be reasonable to avoid anticholinergic exposure in the PICU whenever possible.
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Pediatr Crit Care Me · Jun 2020
Observational StudyEpidemiology of Community-Onset Severe Bacterial Infections in Children and Its Evolution: A Population-Based Study in France.
To describe the epidemiology of community-onset severe bacterial infections in children and its recent evolution. ⋯ The incidence and mortality rate of community-onset severe bacterial infections, except for S. aureus infection, have decreased in France. N. meningitidis and S. pneumoniae continue to account for many infections, which indicates the need for better vaccination coverage and spectrum.
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Pediatr Crit Care Me · Jun 2020
Observational StudyThe Effect of Imputation of PaO2/FIO2 From SpO2/FIO2 on the Performance of the Pediatric Index of Mortality 3.
To investigate if the performance of Pediatric Index of Mortality 3 is improved by including imputed values for the PaO2/FIO2 ratio where measurements of PaO2 or FIO2 are missing. ⋯ Imputation of the PaO2/FIO2 ratio in cases where arterial sampling was not performed resulted in a large reduction in the rate of missing data if all values of SpO2 were included. The imputation technique improved the discrimination of Pediatric Index of Mortality 3; however, the magnitude of the increment in overall model performance was small. A possible benefit of the approach is reducing the potential for bias resulting from variation in practice for invasive monitoring of oxygenation.