An Sist Sanit Navar
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Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) have been associated with a reduction in the risk of developing adenomas and colorectal cancer. The available scientific evidence justifies the need for more studies that evaluate the protective effect of aspirin and other NSAIDs as a preventive measure against cancer of the colon; define the minimum efficient dosage; the age at which to begin treatment; the most convenient duration of the latter; and the sub-populations for which the benefits of chemoprophylaxis outweigh possible adverse effects.
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An Sist Sanit Navar · May 2012
Review[Monogenic human obesity: role of the leptin-melanocortin system in the regulation of food intake and body weight in humans].
Human obesity is a disorder of multifactorial origin in which genetic and environmental factors are involved. To understand the mechanisms regulating energy intake and fat accumulation in the body, it is important to study the genetic alterations causing monogenic obesity. ⋯ Previous studies have described mutations in leptin and its receptor, proopiomelanocortin and prohormone convertase 1 associated with human obesity of monogenic origin. The aim of this study is to provide an updated review of the main characteristics and functioning of the leptin-melanocortin system, and its implications and potentialities in regulating food intake and body weight.
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An Sist Sanit Navar · May 2012
Case Reports[Penetrating ascending aortic ulcer in an asymptomatic patient].
Penetrating aortic ulcer (PAU) has been defined as an atherosclerotic plaque ulceration that breaks the internal elastic lamina of the aorta, which may progress to a wall hematoma or aortic dissection in the case of blood seeping into the middle layer. Although PAU is commonly located in the descending aorta, the involvement of the ascending aorta can be fatal. Therefore, surgery is indicated even in asymptomatic patients presenting an ascending PAU. We report on an asymptomatic patient with ascending PAU referred for replacement of the ascending aorta with a composite prosthetic graft.
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An Sist Sanit Navar · May 2012
[Factors associated with willingness to be vaccinated against pandemic flu A/H1N1 in the adult population of the Health Department of Elche (Spain)].
To assess, in the general population, the information sources, attitudes and willingness to be vaccinated against pandemic influenza A/H1N1 in 2009. ⋯ Low acceptance of the pandemic vaccination and low perceived severity of influenza A/H1N1. Previous vaccination experience with seasonal flu creates a predisposition to immunization against A/H1N1. Although the media were the leading source of information during this period, the family doctor's influence on their decision to be vaccinated was significant.
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An Sist Sanit Navar · May 2012
[Prediction model for in-hospital admission in patients arriving in the emergency department].
To develop a prediction model for in-hospital admission to provide an almost "real time" determination of hospital beds needed, so as to predict the resources required as early as possible. ⋯ The in-hospital admission prediction model is a good and useful tool for predicting the in-hospital beds needed when patients arrive at the emergency department.