Ann Trop Med Parasit
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Ann Trop Med Parasit · Apr 1988
Transcapillary escape rate and capillary permeability to albumin in patients with Plasmodium falciparum.
The transcapillary escape rate and capillary permeability to albumin were studied in five patients with Plasmodium falciparum malaria and six control subjects by using 125I-HSA. The mean transcapillary escape rate of albumin, calculated from the slope of the plasma disappearance curve of 125I-HSA, was found to be significantly higher in the malaria patients than in the control group. ⋯ Both the effective capillary pore area per unit path length available for restricted diffusion and the specific permeability coefficient of the capillary to albumin were found to be grossly elevated in the patients' group. These findings indicated that there was an increased leakage of plasma albumin in patients with P. falciparum malaria as a result of increased capillary surface area and an increased capillary permeability to albumin.