Biomed Environ Sci
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Inhibitory effect of progesterone on inflammatory factors after experimental traumatic brain injury.
Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality in young people. Inflammatory cytokines play an important part in the pathophysiology of TBI. Recent studies demonstrate that progesterone significantly reduces cerebral edema and enhances functional recovery from TBI and stroke in several animal models. This study was designed to investigate the inhibitory effect of progesterone on inflammatory response after traumatic brain injury. ⋯ Progesterone inhibits the inflammatory response after experimental traumatic brain injury and mitigates the severity of brain damage.