P R Health Sci J
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We report a case of a 33-year-old woman with grade IV pulmonary hypertension and end stage cor pulmonale secondary to chronic schistosomiasis (bilharziasis). The pathophysiology and morphologic features are discussed. Schistosomiasis is an important etiology to consider in the differential diagnosis of pulmonary hypertension.
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The steady-state cable equations were used to describe the response of discontinuous neuronal cylinders to extracellular electric fields. Where two unequal diameters join, there forms a strong local peak of membrane polarization. ⋯ In contrast, altering the specific membrane resistance along part of a uniformly shaped axon affects the general level of membrane potential without causing a local peak. Field-effects due to structural discontinuities, although relevant to the interpretation of experiments using electrical stimulation, are shown to be of minor functional consequence compared to chemical gating of membrane current.