Psychosomatic medicine
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Psychosomatic medicine · Nov 2012
Neural dysregulation in posttraumatic stress disorder: evidence for disrupted equilibrium between salience and default mode brain networks.
Convergent research demonstrates disrupted attention and heightened threat sensitivity in posttraumatic stress disorder (PTSD). This might be linked to aberrations in large-scale networks subserving the detection of salient stimuli (i.e., the salience network [SN]) and stimulus-independent, internally focused thought (i.e., the default mode network [DMN]). ⋯ During resting-state scanning, participants with PTSD showed reduced coupling within the DMN, greater coupling within the SN, and increased coupling between the DMN and the SN. Our findings suggest a relative dominance of threat-sensitive circuitry in PTSD, even in task-free conditions. Disequilibrium between large-scale networks subserving salience detection versus internally focused thought may be associated with PTSD pathophysiology.
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Psychosomatic medicine · Nov 2012
Implicit racial bias as a moderator of the association between racial discrimination and hypertension: a study of Midlife African American men.
Empirical findings on racial discrimination and hypertension risk have been inconsistent. Some studies have found no association between self-reported experiences of discrimination and cardiovascular health outcomes, whereas others have found moderated or curvilinear relationships. The current cross-sectional study examined whether the association between racial discrimination and hypertension is moderated by implicit racial bias among African American midlife men. ⋯ The combination of experiencing racial discrimination and holding an antiblack bias may have particularly detrimental consequences on hypertension among African American midlife men, whereas holding an implicit problack bias may buffer the effects of racial discrimination. Efforts to address both internalized racial bias and racial discrimination may lower cardiovascular risk in this population.
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Psychosomatic medicine · Nov 2012
Physical health status of female veterans: contributions of sex partnership and in-military rape.
The aim of this study was to determine whether current physical health status in female veterans is associated with rape during military service and same-sex partnership. ⋯ Both rape and sex partnership are adversely associated with lower physical functioning in female veterans. Clinicians evaluating the physical health of this population should therefore consider obtaining detailed sexual histories, and a multidisciplinary team is needed to address mental health issues in female veterans.
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Psychosomatic medicine · Nov 2012
Peak-end memory bias in laboratory-induced dyspnea: a comparison of patients with medically unexplained symptoms and healthy controls.
Memory for unpleasant experiences is dominated by intensity at the experience's peak and end, with a relative neglect for its duration. Therefore, unpleasant somatic experiences are expected be remembered as less aversive when they end gradually rather than abruptly, even when they last longer (i.e., the "peak-end effect"). We investigated the peak-end effect for dyspnea in healthy participants and in patients with medically unexplained dyspnea (MUD). ⋯ The peak-end effect in dyspnea has important implications for dyspnea measurement. Its absence in patients with MUD suggests a critical role of distorted perceptual-cognitive processing of aversive somatic sensations in patients with medically unexplained symptoms.