Psychosomatic medicine
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Psychosomatic medicine · Apr 2014
Review Meta AnalysisVitamin D supplementation for depressive symptoms: a systematic review and meta-analysis of randomized controlled trials.
The aim of this study was to review the effects of vitamin D supplementation on depressive symptoms in randomized controlled trials. Although low vitamin D levels have been observationally associated with depressive symptoms, the effect of vitamin D supplementation as an antidepressant remains uncertain. ⋯ Vitamin D supplementation may be effective for reducing depressive symptoms in patients with clinically significant depression; however, further high-quality research is needed.