Psychosomatics
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Randomized Controlled Trial
Individual risk profiles for postoperative delirium after joint replacement surgery.
Delirium occurs in nearly half of older patients after joint replacement surgery. However, risk profiles for developing delirium have not been established. ⋯ Although use of prophylactic olanzapine reduced the incidence of delirium, subsets of patients remained likely to develop delirium. The risk of developing delirium may be reduced through prophylactic dispensation of olanzapine, maintaining optimal perfusion and oxygenation, and limiting intra-operative opioids.