British medical bulletin
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British medical bulletin · Nov 2024
Management of knee osteoarthritis using bone marrow aspirate concentrate: a systematic review.
Knee osteoarthritis (OA) is a common degenerative joint condition and a major cause of disability in the general population. ⋯ BMAC is a valuable source of mesenchymal stem cells, offering potential benefits in attenuating the inflammatory pathway associated with knee OA. Intra-articular injection of BMAC has shown effectiveness in clinical trials improving functional outcomes of knee OA patients. The superiority of BMAC over other orthobiological treatments cannot be assessed because of conflicting results.
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British medical bulletin · Nov 2024
High-volume injections in Achilles tendinopathy: a systematic review.
Achilles tendinopathy (AT) is common, particularly in runners. High-volume injections (HVIs) may be beneficial in the management of AT compared to other conservative management options, including exercise regimens, platelet-rich plasma (PRP) injections, and extracorporeal shockwave therapy. The published research on the effectiveness of HVI in the treatment of AT was evaluated in this systematic review. ⋯ More robust randomized controlled trials, with longer-term follow-ups and homogeneity, are needed to fully establish its efficacy for AT.
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British medical bulletin · Oct 2024
Pediatric wrist fractures: variations in management across countries. An evidence-based summary of evidence.
Fractures of the distal radius are common in pediatric population, with considerable variation in the management of pediatric wrist fractures across different countries. It is crucial to consider the different approaches to conservative management and surgical intervention. The decision on the appropriate treatment method often depends on the type and severity of the fracture, as well as the available healthcare resources and expertise in each country. This article tries to identify these variations, so the various healthcare systems can work toward implementing best practices in the management of pediatric wrist fractures on a global scale. ⋯ Efforts to support and prioritize the conduct and dissemination of RCTs in pediatric wrist fracture management can ultimately lead to more consistent, effective, and evidence-based care for children with wrist fractures worldwide.
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British medical bulletin · Sep 2024
New developments in the diagnosis and management of motor neuron disease.
Motor neuron disease (MND) is a devastating neurodegenerative disease characterized by progressive muscle weakness. ⋯ Further work should focus on the elucidation of environmental causes of MND, gene-environment interactions, and advanced cellular models of disease.
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British medical bulletin · Sep 2024
ReviewPharmacological management of secondary chronic spinal cord injury: a systematic review.
Spinal cord injury (SCI) may bring lifelong consequences for affected patients and a high financial burden to the health care system. ⋯ Different approaches exist for the pharmacological management of secondary chronic SCI. One of the most investigated drugs, 4-aminopyridine, improves central motor conduction and shows improvement in neurological signs. Positive results in different areas have been observed in patients receiving the anti-spastic drugs tizanidine and baclofen or Granulocyte colony-stimulating factor. Growth hormone showed only minimal or no significant effects, and the therapy of secondary chronic SCI with riluzole has been poorly researched to date.