British medical bulletin
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Since 2015, an epidemic of Zika virus spread across the Americas. This coincided with an increased incidence of microcephaly reported at birth in Brazil, with subsequent evidence of a causal association. ⋯ Follow-up studies of affected infants are vital to inform on prognosis and guide screening programmes of the future.
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The escalation in the prevalence of obesity throughout the world has led to an upsurge in the number of obese surgical patients to whom perioperative care needs to be delivered. ⋯ What results in an obese patient developing 'unhealthy' obesity?
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British medical bulletin · Dec 2017
Review Comparative StudyOutcome of ankle arthrodesis and ankle prosthesis: a review of the current status.
In advanced stages of ankle osteoarthritis (OA), ankle arthrodesis (AA) or total ankle arthroplasty (TAR) may be necessary. Our purpose is to compare AA and total ankle replacement for the surgical management of end stage ankle OA. ⋯ Systematic review, level III.
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The aim of this review is to bring pancreatic transplantation out of the specialist realm, informing practitioners about this important procedure, so that they feel better equipped to refer suitable patients for transplantation and manage, counsel and support when encountering them within their own speciality. ⋯ Therapies to alleviate problems associated with ischaemia reperfusion injury, graft pancreatitis and more effective monitoring methods for detecting and treating organ rejection are the key areas of growth.
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British medical bulletin · Dec 2017
ReviewFriedreich's ataxia: clinical features, pathogenesis and management.
Friedreich's ataxia is the most common inherited ataxia. ⋯ Management of Freidreich's ataxia is currently focussed on symptomatic management, delivered by the multidisciplinary team. Phase II clinical trials in agents that address the abberrant silencing of the frataxin gene need to be translated into large placebo-controlled Phase III trials to help establish their therapeutic potential.