British medical bulletin
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British medical bulletin · Oct 2020
Covid-19 and the 'new normal': are remote video consultations here to stay?
During the UK Covid-19 lockdown, video consultations (telemedicine) were encouraged. The extent of usage, and to which concerns to earlier implementation were set aside, is unknown; this is worthy of exploration as data becomes available. ⋯ Examination of telemedicine use during the Covid-19 crisis to ensure that the benefits and usage continue into the post-lockdown, 'new normal' world.
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British medical bulletin · Oct 2020
The challenges presented by haematopoietic stem cell transplantation in children with primary immunodeficiency.
For many primary immunodeficiencies (PIDs), haematopoietic stem cell transplantation (HSCT) offers treatment to cure disease. However, patients with PID present a unique set of challenges when considering HSCT. ⋯ International collaborations are important to learn about rare presentations and complications, and to formulate the most effective and safe treatment strategies.
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Tendon is a composite material with a well-ordered hierarchical structure exhibiting viscoelastic properties designed to transfer force. It is recognized that the incidence of tendon injury increases with age, suggesting a deterioration in homeostatic mechanisms or reparative processes. This review summarizes epigenetic mechanisms identified in ageing healthy tendon. ⋯ Metanalysis through integration of multiple datasets and platforms will enable a holistic understanding of the epigenome in ageing and its relevance to disease.
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Suicidal behaviours and non-suicidal self-harm (NSSH) are global public health concerns that affect millions of lives. ⋯ Whilst some psychosocial interventions can be effective in reducing suicide risk, little is known about the mechanisms of recovery from suicidal thoughts and behaviours.
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British medical bulletin · Jul 2020
ReviewHealth inequalities are worsening in the North East of England.
The North of England, particularly the North East (NE), has worse health (e.g. 2 years lower life expectancy) and higher health inequalities compared to the rest of England. ⋯ Research to understand and reduce health inequalities is needed particularly in the NE of England where reductions could have enhanced the impact.