Crit Care Resusc
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Observational Study
Filter lifespan in critically ill adults receiving continuous renal replacement therapy: the effect of patient and treatmentrelated variables.
To examine the effects of patient and treatment-related variables on filter lifespan in critically ill adults receiving continuous renal replacement therapy (CRRT). ⋯ Our study found that an increased CRRT filter lifespan is associated with higher blood flow rates and lower platelet count. Vascular catheter design may also be a factor.
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Randomized Controlled Trial Comparative Study
A pilot trial of bordered polyurethane dressings, tissue adhesive and sutureless devices compared with standard polyurethane dressings for securing short-term arterial catheters.
To improve arterial catheter (AC) securement and reduce AC failure; to assess feasibility of a large randomised controlled trial. ⋯ AC failure occurred significantly less often with BPU + SPU dressings than with SPU dressings. TA + SPU and SSD + SPU dressings should be further investigated and compared with BPU + SPU dressings as controls. The novel approach of TA + SPU dressings appeared safe and feasible.
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Randomized Controlled Trial
Pharmacokinetics of short versus extended infusion meropenem dosing in critically ill patients: a pilot study.
To test whether a prolonged 3-hour infusion of meropenem 500mg achieves an equivalent proportion of time above the minimal inhibitory concentration (MIC) (%TMIC) to that of meropenem 1000mg given over 30 minutes. ⋯ Meropenem at 1000mg over 30 minutes achieved a similar %TMIC to meropenem at 500mg given over 3 hours. Meropenem pharmacokinetics were highly variable from individual to individual.
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To establish the prevalence of emergency responses for clinical deterioration (cardiac arrest team or medical emergency team [MET] activation) within 24 hours of emergency admission, and determine if there were differences in characteristics and outcomes of ward patients whose emergency response was within, or beyond, 24 hours of emergency admission. ⋯ One-quarter of emergency responses after admission via the ED occurred within 24 hours. Further research is needed to understand the predictors of deterioration in patients needing emergency admission.