Crit Care Resusc
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Randomized Controlled Trial
Evaluation of urea and creatinine change during continuous renal replacement therapy: effect of blood flow rate.
To determine if faster blood flow rate (BFR) has an effect on solute maintenance in continuous renal replacement therapy. ⋯ Faster BFR did not affect solute control in patients receiving CRRT; however, differences in urea and creatinine concentrations were influenced by serum haemoglobin and hours of treatment.
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Randomized Controlled Trial Multicenter Study
Study protocol for the Augmented versus Routine Approach to Giving Energy Trial (TARGET).
Nutrition is routinely provided to critically ill patients who are mechanically ventilated and remain in the intensive care unit for more than a few days. Nasogastric feeding, which is standard practice for patients who are unable to tolerate oral nutrition, typically delivers less than 60% of the recommended energy requirements. It remains uncertain whether the delivery of about 100% of the recommended energy goals via the enteral route will affect survival and other important clinical outcomes. ⋯ The results of this trial are expected to determine whether increased energy delivery, using an energy-dense formula can improve clinically meaningful outcomes, including survival.
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Observational Study
Smoking cessation therapy in Australian and New Zealand intensive care units: a multicentre point prevalence study.
To obtain an accurate estimate of smoking prevalence and smoking cessation support practices, including nicotine replacement therapy (NRT), in Australian and New Zealand intensive care units (ICUs). ⋯ The prevalence of smoking in Australian and New Zealand ICUs patients is high. Over half of participating ICUs reported the routine prescription of NRT despite uncertainty regarding the practice. Further research evaluating the safety and efficacy of NRT is required.
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Randomized Controlled Trial
Proportional assist ventilation versus pressure support ventilation in weaning ventilation: a pilot randomised controlled trial.
Proportional assist ventilation with load-adjustable gain factors (PAV+) is a mode of ventilation that provides assistance in proportion to patient effort. This may have physiological and clinical advantages when compared with pressure support ventilation (PSV). Our objective was to compare these two modes in patients being weaned from mechanical ventilation. ⋯ Both modes of ventilation were comparable in time to liberation from the ventilator.
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Randomized Controlled Trial
Statistical analysis plan for the Augmented versus Routine Approach to Giving Energy Trial (TARGET).
The Augmented versus Routine Approach to Giving Energy Trial (TARGET) is a 4000-patient randomised, double-blind controlled trial designed to evaluate whether enteral delivery of recommended energy goals using a 1.5 kcal/mL enteral nutrition formulation improves clinical outcomes, compared with a 1 kcal/mL enteral nutrition formulation delivered at the same goal rate, in critically ill patients receiving invasive mechanical ventilation. ⋯ We have developed a pre-specified statistical analysis plan for TARGET. To minimise analytical bias, this plan has been developed and made available to the public domain before completing recruitment and data collection.