Crit Care Resusc
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Near-infrared spectroscopy (NIRS) has been used in clinical practice to assess regional cerebral tissue oxygen saturation (StcO2). There is no evidence whether repeated use of the same sensor affects StcO2 measurements. We aimed to assess whether there was a significant systematic decrease or increase in StcO2 when NIRS sensors were reused. ⋯ Repeated use of NIRS sensors measured StcO2 in different individuals for up to 10 days. There were no significant, systematic, persistent or progressive changes in StcO2 with extended use over time. Our findings suggest that StcO2 does not change with sensor reuse for up to 10 days.
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The cluster randomised crossover (CRXO) design provides an opportunity to conduct randomised controlled trials to evaluate low risk interventions in the intensive care setting. Our aim is to provide a tutorial on how to perform a sample size calculation for a CRXO trial, focusing on the meaning of the elements required for the calculations, with application to intensive care trials. ⋯ The CRXO design enables the evaluation of routinely used interventions that can bring about small, but important, improvements in patient care in the intensive care setting.
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Observational Study
Predicting recovery from acute kidney injury in critically ill patients: development and validation of a prediction model.
Intensive care unit (ICU) patients with acute kidney injury (AKI) who recover kidney function within 28 days experience less severe chronic kidney impairment and have increased long term survival. The aims of this study were to develop and validate a risk prediction model to identify these patients. ⋯ We constructed and validated a simple model that can predict the chance of recovery from AKI in critically ill patients.
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Randomized Controlled Trial
Statistical analysis plan for the Augmented versus Routine Approach to Giving Energy Trial (TARGET).
The Augmented versus Routine Approach to Giving Energy Trial (TARGET) is a 4000-patient randomised, double-blind controlled trial designed to evaluate whether enteral delivery of recommended energy goals using a 1.5 kcal/mL enteral nutrition formulation improves clinical outcomes, compared with a 1 kcal/mL enteral nutrition formulation delivered at the same goal rate, in critically ill patients receiving invasive mechanical ventilation. ⋯ We have developed a pre-specified statistical analysis plan for TARGET. To minimise analytical bias, this plan has been developed and made available to the public domain before completing recruitment and data collection.