Brain Stimul
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To address the brain areas and circuits affected by transcranial electrical stimulation (tES), which had been used widely to treat psychiatric and neurological diseases, the stimulus-induced electric field in the cortex was calculated using a head model that reflects anatomical information. To obtain detailed information at the macroscopic and microscopic levels, multi-scale modeling was proposed that integrates the head model with multi-compartmental models of cortical neurons. ⋯ Our results indicated that cortical neurons are affected greatly by the relative direction of the stimulus-induced electric field, which may be a necessary step toward a detailed understanding of tES' potential mechanisms.
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The ventral anterior limb of the internal capsule (vALIC) is a target for deep brain stimulation (DBS) in obsessive-compulsive disorder (OCD). Conventional surgical planning is based on anatomical landmarks. ⋯ These findings suggest that vALIC DBS for OCD may benefit from MFB-specific implantation and highlight the importance of corticolimbic connections in OCD response to DBS. Prospective investigation is necessary to validate the clinical use of MFB targeting.