Can J Neurol Sci
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Comparative Study Clinical Trial Controlled Clinical Trial
A comparison of bromocriptine (Parlodel) and levodopa-carbidopa (Sinemet) for treatment of "de novo" Parkinson's disease patients.
Fifty-one patients were enrolled in a double-blind, parallel group, multicentre study conducted to assess short-term efficacy and tolerance of bromocriptine (Parlodel) or L-DOPA/carbidopa (Sinemet) in patients never treated with amantadine, ergot alkaloids or L-DOPA-based drugs. An attempt to use the lowest effective dose was made. ⋯ Comparison between groups did not show any significant difference for both neurological and disability assessments. The most frequent side effect was nausea (L-DOPA, N = 3; bromocriptine, N = 6).
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Historical Article
Commentary on the significance for modern neurology of the 17th century B.C. Surgical Papyrus.
A 17th century B. C. Surgical Papyrus known as "The Edwin Smith Papyrus" was published in facsimile and hieroglyphic transliteration with translation and commentary by James Henry Breasted in 1930. ⋯ C. It is of importance to the history of Neurology as it contains the earliest mention in oriental literature of (a) the brain and meninges (b) calvarial and cervical vertebral injuries in details of pathology, symptomatology, treatment and prognosis and (c) functional localization in the brain and spine. Most importantly, Papyrus Smith is a statement of the medical ethic of its time.