Neurol Neurochir Pol
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Neurol Neurochir Pol · May 1986
Comparative Study Clinical Trial Controlled Clinical Trial[Morphine epidural block in lumbosacral pain].
In 60 patients treated in hospital for discopathy the effectiveness of morphine epidural blockade was studied in the control of very strong pain. The patients were divided into 3 groups with 20 cases in each group. Group I received morphine 5 mg with 5 ml of 1% xylocaine. ⋯ After morphine blockades the mean duration of analgesia was 20 hours, and the addition of xylocaine had no effect on it. Following xylocaine blockade the mean time of analgesia was 9.8 hours, and after normal saline injection it was 8.0 hours. The sensory phenomena experienced after morphine by most patients suggest that morphine exerts not only a local but also a central effect, while the similarity of the effects of xylocaine and normal saline suggests an analgesic effect independent of conduction block after epidural injection of these substances.